McGuire served in all the major battles of the Army of Northern Virginia as the medical director of the famed Second Corps. In May of 1863, Jackson was wounded in the arm by friendly fire at the battle of Chancellorsville. After a week long battle with pneumonia, Jackson died of the pneumonia. (note: modern physicans think Jackson probably died of a pulomanry embolism, not pneumonia as McGuire thought) A picture of McGuire taken in mid-May shows him looking gaunt and exhausted, both indicative of the tireless efforts he put forth in an attempt to save his friend and patient. In fact, Dr. McGuire attempted to give his patient and friend round the clock care.

