The UVM College of Medicine has had a role in medical education for nearly 200 years. In 1804, Dr. John Pomeroy began teaching students in his house on Battery Street in Burlington, and later that year the University of Vermont established the first medical department at a state college or university. In 1822, the College of Medicine was established as the seventh medical college in the United States. Two of its founders were Dr. Pomeroy and the pioneering medical educator Nathan Smith.
The two centuries since its founding have seen the College of Medicine go through many changes that have mirrored the changes in all areas of health care.

