Henry Solomon Wellcome was born half a world away from the Sudan in the American Midwest in 1853. His personal qualities and attitudes to life have been shaped in his early years. The Wellcome family was deeply religious , his father and two uncles were ministers of the Adventist sect. When Henry was eight, his family moved to Garden City, Minnesota where his other uncle, Jacob Wellcome was in medical practice.
In the 1860ies the Midwest was still frontier country. Shortly after the family settled in Garden City there was an Indian uprising in the area. Over 2000 settlers were killed and the towns were transformed to small fortresses defended by volunteers and troops. The young Henry helped his uncle in caring for the wounded and he was also appointed captain to a group of children casting rifle bullets for the settlers. The uprising ended in an Indian defeat and the public hanging of 38 Sioux Indian chiefs. This event created in Wellcome a life-long awareness of the suffering of the dispossessed peoples in whom he saw the suffering of mankind. Later in his life, for many years he supported missionary work among a group of American Indians.

